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KMID : 1156220060320010067
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Journal of Environmental Health Sciences
2006 Volume.32 No. 1 p.67 ~ p.70
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The Study on the Measurement of Formaldehyde in Hair by HS-GC-MS
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Shin Ho-Sang
Ahn Hey-Sil
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Abstract
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A gas chromatography/mass spectrometric method was developed for the determination of formaldehyde in hair. 0.3 ㎎ of hair was placed in 10 ㎖ headspace vial. 1.5 mM pentafluorophenylhydrazine solution (pH 2) in 0.03 M phosphoric acid and 20 ㎕ of 500 ㎎/ℓ acetone-d_6 as internal standard were added in vial and sealed tightly with cap. The solution was heated for 30 min at 90℃ in heating block. The extraction, the derivatization and the evaporation were performed simultaneously. After heating of the solution, 0.5 ㎖ of headspace was taken up and analyzed by gas chromatography-mass spectrometry (GC-MS). Low limit of detection (LOD) and Low limit of quantitation (LOQ) of formaldehyde were 0.5 and 1.5 ng/g, respectively. The method was used to analyze formaldehyde in rat hair after oral exposure. The developed method may be valuable to be used to analyze formaldehyde in human hair.
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